Topic 3 Impact on tumorigenesis

Excess consumption TFA, an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome.

Trans isomers of fatty acids can cause intestinal tumours (Schroeder et al., 2008). Little information is known about the influence of trans fatty acid consumption on the formation of colon tumours, but there are several mechanisms in the body by which these acids may influence the formation of colorectal tumours. Consumption of trans-fatty acids can increase the likelihood of rectal tumours by altering the levels of fatty and bile acids in the colon. This may be the result of irritation of the colon caused by oxidative stress. Trans-fatty acids interfere with gene transcription and this can initiate prostate tumour and epithelial metastases, tumours and tumour formation (SkabeikytÄ—, n.d.).

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